The hands are blistered and wrinkled severely, if there is no discomfort, it is mostly a normal phenomenon. If accompanied by uncomfortable symptoms, may be caused by ringworm. 1. Normal phenomenon: when the hand is immersed in water for a long time, the local skin cells will absorb water and thus expand, when the local volume increases. The oil will be removed by the water, the skin is prone to wrinkles. If not accompanied by other uncomfortable symptoms, mostly normal phenomenon, when out of the water-immersed environment, the symptoms can be relieved on their own, no need to worry. 2. Ringworm: ringworm is caused by dermatophyte infection, or may be induced by the hands in a humid environment, sweating and other factors. After the patient’s hands are soaked in water, the wrinkles can appear serious, and accompanied by small blisters, itchy skin and other symptoms. There are many reasons that lead to severe wrinkles after the hands are blistered, and patients are advised to identify the cause of the disease in time.