Heart disease generally develops to advanced stage, indicating that the progress of the disease is more serious, mostly manifested as heart failure, when the physical symptoms of the patient will become more and more serious, the following we will understand the late symptoms of heart disease. 1, skin cyanosis The skin of patients with chronic heart failure and advanced heart disease can be dark brown or dark purple, which is related to long-term hypoxia of body tissues and decreased adrenal cortical function, the skin mucosa and limb cyanosis indicates extreme hypoxia of the heart. 2, pestle finger (toe) The end of the finger or toe of the patient’s hands and feet is obviously thick, and the nail surface is raised like a drumstick, which is common in chronic pulmonary heart disease or cyanotic heart disease. 3, edema Middle-aged and elderly people may have lower limb edema due to obstruction of venous blood return caused by cardiac insufficiency, head and facial swelling in the upper body, chest and abdominal fluid, jugular vein anger and hepatomegaly, and frequent palpitations and shortness of breath, which can only be relieved by adopting squatting position. 4.Large amount of hemoptysis Acute left heart failure caused by heart disease, airway obstruction can be hemoptysis, into pink or bright red foamy sputum, or even a large amount of hemoptysis. 5, syncope is mainly due to a sudden decrease in cardiac blood output, temporary ischemia of brain tissue caused by a brief loss of consciousness, there will be sudden syncope.