Macrophages in the liver, also known clinically as kwashiorkor cells, are immune cells that deal with immunomodulatory reactions and participate in the immune response in the body. Their location is mainly in the blood sinusoids of the liver, and their specific functions are to participate in metamorphosis and phagocytosis, as well as to process and deliver antigens and regulate the immune response and other immune reactions in the body. They are mononuclear phagocytes whose main role, in clinical practice, is to remove bacteria and viruses from the liver. If the body is infected with bacteria or viruses, especially in the liver area, they are mostly engulfed by macrophages. In the body, macrophages are also involved in the body’s defense response and can play a defensive role in the event of liver damage by releasing various inflammatory mediators. Patients with liver damage, such as alcoholic hepatitis, and other liver damage, such as autoimmune hepatitis, may also experience an increase in blastocytes in the body, which is mostly a response to the body’s immune defense response. In this case, patients need to actively apply hepatoprotective drugs for hepatoprotective treatment, such as diammonium glycyrrhetinate and reduced glutathione, patients need to pay attention to actively relieve the body’s inflammatory response.