Sore hands and feet on the second day of drinking may be caused by improper sleeping posture, catching a cold, alcohol stimulation and other factors. 1. Improper sleeping position: If you drink alcohol and sleep in an improper position, it may lead to the hands and feet for a long time in a state of compression, thus appearing the next day after waking up, hands and feet sore. 2. Cold: If you don’t pay attention to keeping warm when you sleep after drinking alcohol, and your hands and feet are stimulated by cold, it may lead to the continuous contraction of blood vessels in the muscles, which puts the muscles in a state of tension for a long period of time, and may lead to muscle stiffness and muscle spasms, which may lead to soreness of hands and feet on the next day. 3. Alcohol stimulation: after drinking alcohol, especially alcoholism, the blood alcohol concentration increases, which may stimulate the muscle nerves, making them in a state of excitement, resulting in an increase in anaerobic metabolites such as lactic acid, which leads to the next day of sore hands and feet. Sore hands and feet the next day after drinking may also be caused by gout, if the symptoms persist, you should go to the hospital in time, under the guidance of the doctor standardized treatment.