AIDS itself does not cause blisters (blisters) on the lips, but due to immunocompromise it is easy to combine with herpes virus infection, resulting in herpes on the lips and mouth. The disease may last longer and be more difficult to heal than in normal people. AIDS can be categorized into acute, asymptomatic and AIDS stage. If lip blistering occurs in the acute or asymptomatic stage (lasting about 6-8 years), there is generally no significant difference from normal people. AIDS period of low body immune function if combined with herpes virus infection can appear lips and mouth herpes, manifested as erythema, cluster blisters, pustules, blisters can be ruptured and fusion, accompanied by fever and malaise and other systemic symptoms, the course of the disease compared to the normal person will generally be longer, the trauma is more difficult to fusion, more likely to be combined with other bacterial and viral infections. To summarize, AIDS lip blistering performance is similar to normal infection with herpes virus, but the symptoms are more serious, can be repeatedly infected, long-term non-healing, easy to secondary bacterial infections and so on. Once AIDS is diagnosed, it is necessary to follow the doctor’s instructions to carry out antiretroviral treatment as soon as possible, so as not to delay the condition.