High total iron binding capacity is caused by the presence of iron deficiency anemia, liver cell injury and other diseases that cause the body’s serum iron and transferrin to fail to bind iron, resulting in an elevated total iron binding capacity. When high total iron binding is suspected, routine blood tests and serum iron should be performed. To regulate the total iron binding capacity, pay attention to a light diet, eat more foods that contain more vitamins and fiber, such as vegetables and fruits, and do not eat high-calorie, high-fat foods as well as spicy and stimulating foods. Also pay attention to the work and rest schedule, do not stay up late, regulate your mood and reduce mental stress, all of which are conducive to the smooth binding of serum iron and transferrin to iron. If the total iron binding capacity continues to show high levels, it is necessary to use medication under the guidance of a doctor to enhance the binding of serum iron and transferrin with iron in the body.