The current treatment rate of Parkinson’s disease in China is very low, and there are often problems of misdiagnosis and underdiagnosis. Due to misdiagnosis or incorrect treatment, patients with Parkinson’s disease who have indications for surgery are deprived of surgical treatment, and the diagnosis of some patients is even delayed for more than six months. The main reason why Parkinson’s is so easily misdiagnosed is that there are many diseases that are very similar to Parkinson’s disease in terms of clinical manifestations, which are not easy to identify and can lead to mistakes if you are not careful. In the early stages of the disease, Parkinson’s disease is often misdiagnosed as cerebral arteriosclerosis and cerebral atrophy. Most of these two types of diseases have symptoms such as limited mobility and light tremors in the limbs, which are very similar to Parkinson’s disease. Parkinson’s disease is also often diagnosed as cerebrovascular disease such as cerebral infarction because of the same symptoms such as stiffness and difficulty walking. Some patients with Parkinson’s disease also have symptoms of dementia, memory loss, cognitive difficulties, or with psychiatric symptoms, which can also be easily misdiagnosed as Alzheimer’s disease. Some patients with Parkinson’s disease may also show a reduced desire to live, reduced language, decreased thinking and judgment, etc. What are the clinical manifestations of Parkinson’s disease? Tremor: It often starts on one side of the hand, with tremor evident during quiet times, and slowly progresses to the upper and lower extremities, head and trunk areas. Tremors may be reduced or disappear during exercise, disappear after sleep, and worsen during emotional or stressful situations. Muscle stiffness: as if the body is tied with a rope. Slower movements: slower movements such as dressing, buttoning, brushing teeth, washing face, etc., difficulty getting in and out of bed, and increasingly smaller writing. Unstable posture: the body leans forward when standing naturally, the arms swing decreases when walking, and falls easily, especially when turning. Gait disorder: walking with dragging steps, often starting from one side and gradually accumulating to both sides; when getting up and walking, the feet feel like sticking to the ground, unable to take a step, walking with small steps forward, walking faster and faster, unable to stop in time. Early on, there is hyposmia or loss of sense of smell, accompanied by non-motor symptoms such as anxiety, depression, constipation, insomnia, cognitive difficulties, pain or numbness in different degrees. How can misdiagnosis be minimized and accurately determined? Although symptomatology is an effective means of determining Parkinson’s disease, confirming the diagnosis cannot rely solely on symptoms, but requires a series of physical examinations, examinations and some other clinical diagnoses, based on the patient’s medical history, physical examination and observation of the response to dopamine medications, and even the need for ongoing follow-up to make a basic determination. On the other hand, there should be a change in the concept of Parkinson’s disease treatment. In reality, it is widely believed that Parkinson’s disease is a neurological disease and the priority treatment is medication, but as the “honeymoon period” of medication fades away, the efficacy of treatment gradually diminishes. At this time, surgical treatment can provide patients with a second “honeymoon period”, namely brain pacemaker surgery, which is minimally invasive, reversible and adjustable, and can improve bilateral limb symptoms at the same time, making the treatment effect lasting.