The condition of spots on both sides of the corners of the mouth is considered to be related to hyperpigmentation. For example, the patient previously existed in the keratitis or perioral dermatitis and other diseases, in the above inflammation subsides by itself or after treatment to get subsided, there may be left behind the phenomenon of hyperpigmentation, also known as post-inflammatory hyperpigmentation. This belongs to the skin acute inflammation or chronic inflammation caused by inflammatory substances will stimulate the epidermal melanocytes to synthesize melanin, surprisingly, melanin increases, causing the above symptoms. Patients with symptoms of spots on both sides of the corners of the mouth, if there are no other symptoms, you can choose to temporarily observe. If you feel that it affects the aesthetic appearance, then you can cooperate with the doctor to choose the way of laser treatment or external use of hydroquinone cream and other drugs, so as to improve the patient’s symptoms. Normally need to do a good job of sun protection, so as not to aggravate the pigmentation. It is recommended that patients who are willing to be treated go to a regular medical institution and follow the advice of the specialist to choose the appropriate treatment plan.