There are many causes and factors involved in ankle pain, mainly considering the following aspects: first, local injury and strain, due to acute violent trauma or chronic cumulative injury, causing pain in the ankle joint. The second one is due to infection, which is caused by bacterial infection resulting in localized infectious inflammation leading to pain. Third, pain due to aseptic inflammation, such as arthritis, may also be associated with pain. Fourth, bone tumors are considered to cause pain due to tumors of the bone. Fifth, systemic metabolic diseases, such as gout, can also cause pain in the joint. Therefore, there are many factors involved in pain in the ankle joint, and it is recommended to go to the hospital for detailed examination.