Nails with vertical lines and unevenness may be associated with lichen planus, onychomycosis, psoriasis nails and trauma. 1. Nail lichen planus is a chronic inflammatory skin disease of unknown origin, which can be characterized by thickening of the nail plate, roughness of the nail plate and unevenness. 2. Tinea cruris is a skin disease caused by the infection of toenails with ringworm bacteria, which can cause damage to the nail bed and nail plate, so the nails may appear vertical lines or unevenness. 3. Psoriasis nail means that the nail is affected on the basis of psoriasis, which is mainly manifested as thimble-like depression on the surface of the nail, and the shape of the nail will also be changed. 4. Trauma to the nail mother, nail plate and nail bed can lead to abnormal nail morphology, including vertical lines or surface roughness and so on. Due to the differences in clinical manifestations, a doctor’s consultation is required.