Bleeding on the forty-fifth day of frozen embryo transfer is not normal, and you need to consult a doctor in time for examination, which may be caused by preeclampsia, ectopic pregnancy, cervical disease and other reasons. 1. Pre-eclampsia: pregnant women may be due to luteal insufficiency, external stimuli and other reasons, resulting in unstable embryo implantation, vaginal bleeding and other signs of pre-eclampsia, pregnant women need to stay in bed and under the guidance of the doctor for fertility preservation treatment. 2. Ectopic pregnancy: pregnant women in the hospital ultrasound examination, the embryo can be diagnosed if the embryo bed outside the uterine cavity. If the embryo cannot develop normally outside the uterine cavity, miscarriage or rupture may occur and vaginal bleeding may occur. 3. Cervical diseases: pregnant women with cervical polyps and other cervical diseases are likely to have cervical polyp bleeding. Frozen embryo transfer forty-five days of bleeding, you need to actively seek medical examination, to clarify the cause, and follow the doctor’s instructions for treatment.