Damage to liver and kidney function from HIV blocking drugs varies from person to person. And it is related to the drugs used. Many blocking drugs for HIV have some damage to liver and kidney function, such as tenofovir, lamivudine, efavirenz, abidol, and so on. The degree of damage and side effects are different for each drug, and the degree of damage to liver and kidney function varies according to the drug used. In addition if there is a combination of underlying diseases of liver and kidney function such as glomerulonephritis, nephrotic syndrome, viral hepatitis, etc., these patients are at risk of more severe damage to liver and kidney function if they use the drug. After high-risk behavior, it is recommended that the use of blocking drugs should be carried out under the guidance of specialists, so as not to cause serious consequences due to excessive concern about side effects.