Calf bone pain when pressed consider soft tissue injury, fracture, osteoarthritis, osteomyelitis, cardiac and renal diseases, suggest to consult the relevant departments. Soft tissue injury in the calf due to trauma or excessive exercise may cause pain with localized swelling. Orthopaedic consultation is recommended, with rest, localized hot compresses, physiotherapy (short microwave), application of pain relieving drugs (ibuprofen capsule, flurbiprofen ester cream) and swelling reducing drugs (Panlong Qi Tablet). Fractures can be caused by trauma or pathologic causes (tumor), with pain on pressure, fair fracture alignment, external fixation with plaster, and oral pain medication. If the fracture is poorly aligned, surgery is recommended. For local tumor, bone grafting with internal fixation after bone scraping. If the tumor is malignant, local osteotomy is recommended. In addition to local bone pressure pain, osteomyelitis is also accompanied by fever, local temperature rise, acute stage with sinus tract pus, it is recommended to carry out puncture drainage of pus, oral antibiotics (vancomycin), pain relieving drugs. If necessary, surgery is performed to debride. Cardiac and renal diseases, can cause swelling in the calf area, pain when pressed, local soft tissue depression after pressing, it is recommended to go to the cardiology and endocrinology department. Calf bone pain when pressed is recommended to actively seek medical advice and treatment under the guidance of a physician.