Patients with membranous nephropathy can apply penicillin treatment if it is due to bacterial infection and other reasons, but the drug has no therapeutic effect on membranous nephropathy. Membranous nephropathy is a type of renal pathology, mostly manifested as nephrotic syndrome, which is mainly caused by autoimmune causes or other secondary factors, such as systemic lupus erythematosus, tumors, drugs and so on. Treatment is mainly to reduce urinary protein, applying immune preparations if necessary, penicillin has no therapeutic effect on the disease. At this time, patients are prone to infection complications, if the infection is caused by bacteria sensitive to penicillin, penicillin can be applied for treatment. If the patient’s glomerular filtration rate has decreased, the dosage of penicillin needs to be adjusted according to the patient’s degree of decline in renal function. Penicillin is a prescription drug, which may lead to allergies and other serious complications, and needs to be applied under the guidance of a physician.