Albumin to globulin ratio is the ratio of albumin to globulin, and its low ratio may be caused by liver injury and M-proteinemia. 1. Liver injury: In common diseases such as cirrhosis, hepatitis and hepatocellular carcinoma, the liver is damaged, resulting in a decrease in albumin production; in viral hepatitis such as hepatitis B, the immune system is activated due to the invasion of the hepatitis B virus and the production of globulin is increased, which also leads to a low albumin-to-globulin ratio. 2. M-proteinemia: In diseases such as multiple myeloma, macroglobulinemia, malignant lymphoma, etc., the body produces an immune response, the immune system produces more globulin, and the albumin ratio will be low. When abnormal results of white globule ratio test are found, patients should consult relevant departments in time for further examinations, such as liver function, abdominal ultrasound, Hepatitis B 5, protein electrophoresis, immunoglobulin quantification, etc., so that professional doctors can evaluate the condition together with the symptoms of the patients, and then diagnose the disease and give it standardized treatments.