Esophageal cancer, also called esophageal cancer, is a malignant tumor occurring in the epithelial tissue of esophagus, accounting for 2% of all malignant tumors. The main manifestation of pain in esophageal cancer patients is pain in the anterior chest, especially pain behind the sternum or pain in the upper abdomen. Generally, in the early stage of esophageal cancer, pain behind the sternum is often caused when swallowing food, high esophageal cancer can cause pain in the neck, lower esophageal cancer can cause pain under the saber or in the upper abdomen, and patients with advanced esophageal cancer often have heavy feeling and dull pain in the anterior chest, back and scapula. So how to reduce the pain of advanced esophageal cancer patients? Most patients will have difficulty in swallowing, food reflux, weakness, and weight loss due to the damage caused by surgery and radiotherapy, which bring great pain to patients. For advanced esophageal cancer, it is especially important to reduce the pain of advanced esophageal cancer patients and improve the quality of life. The reason why patients with advanced esophageal cancer have a series of extremely painful symptoms is related to the widespread spread of cancer on one hand and the damage brought by treatment on the other. Radiotherapy is a common treatment method for advanced esophageal cancer, which has a more direct inhibitory effect on cancer, but due to the lack of selectivity, it also has a greater harm to normal cells of human body, which makes patients’ immune function impaired, resistance decreased, and a series of radiotherapy complications appear, which hinder the treatment. Only by improving this situation can treatment be carried out smoothly and is fundamental to alleviate the pain of patients with advanced esophageal cancer. Clinically, more and more doctors are aware of the importance of improving the quality of life of patients with advanced esophageal cancer. Patients with advanced esophageal cancer should also pay attention to their daily diet, and correct eating habits can improve the symptoms of advanced esophageal cancer and reduce the pain of advanced esophageal cancer patients to a certain extent. The main principles of food selection in advanced esophageal cancer are: prohibition of spicy and stimulating food, such as chili, raw onion, ginger and garlic; prohibition of rough, hard and hot food; prohibition of moldy, rotten and spoiled food, less smoked and pickled food; prohibition of smoking and alcohol.