Children may experience fever after ordering atropine (generally referred to as atropine sulfate ophthalmic gel), which is a type of unusual adverse drug reaction and should be closely monitored when applied. Atropine sulfate ophthalmic gel is indicated for iridocyclitis, dilation of the pupil prior to fundus examination, and dilation of the pupil prior to refractive error in optometry. Adverse reactions include dryness of the skin and mucous membranes, fever, facial flushing, and tachycardia may occur after ocular administration. In a few patients, allergic phenomena such as itching, redness, swelling of the eyelids, conjunctival congestion, etc. should be discontinued immediately. When a fever occurs after children order atropine sulfate ophthalmic gel, it can be physically retreated, if the temperature remains high, consult a doctor in time to avoid serious consequences.