Both nucleic acid testing and antigen testing are relevant tests for new coronaviruses. Nucleic acid abnormalities that are fine for antigen testing may be due to experimental factors that make either test inaccurate. Abnormal results on nucleic acid tests may be due to factors such as neocoronavirus vaccination prior to the test, or taking medications to treat neocoronavirus infections. Abnormal results on the antigen test are mainly due to low viral load in the body and insensitivity of the antigen test. Generally both tests are based on nucleic acid test results. Abnormal nucleic acid test usually means a positive nucleic acid test result, and a clean antigen test usually means a negative antigen test. Due to the low sensitivity and specificity of antigen detection, when the viral load in the body is low, the protein content on the surface of the virus is also low, and at this time, the antigen test may not be able to show a band due to the low protein content, resulting in a false-negative antigen test. Nucleic acid detection is the use of real-time fluorescence quantitative PCR method to directly amplify the viral RNA, even a particularly small amount of viral nucleic acid can also be amplified. In the above cases, nucleic acid test can be performed again to confirm the diagnosis, and the result of nucleic acid test is the gold standard for diagnosis.