People with fire at the corners of the mouth should drink more water and eat more fresh vegetables and fruits to replenish vitamin C. They can also take vitamin C effervescent tablets, vitamin B6 tablets, vitamin B12, etc., all of which are beneficial to the healing of blisters and fissures at the corners of the mouth. If the fire at the corner of the mouth causes a fissure, the patient should avoid opening the mouth widely when talking, biting and yawning to prevent the deepening and widening of the fissure. People with fire can take medications to clear heat and remove fire, such as clear fire gardenia and wheat tablets, Andrographis tablets, Shuang Huang Lian oral liquid, and Niu Huang Shang Qing Wan. Herpes in the area of fire at the corners of the mouth, mostly due to infection with the herpes simplex virus, can be treated locally with the need to apply acyclovir ointment antiviral. If the fissure appears red, swollen and vesicular, it indicates a secondary bacterial infection and requires the application of erythromycin ointment for anti-inflammatory purposes.