The manifestations of rabies can be categorized into prodromal and post-progressive symptoms. Prodromal symptoms : Rabies is not usually considered during the prodromal phase, which begins with nonspecific symptoms such as low-grade fever, chills, malaise, myalgia, malaise, fatigue, anorexia, sore throat, nausea, vomiting, headache, and occasionally photophobia. The prodromal period lasts from a few days to about 1 week. Patients may describe a variety of symptoms, including pain, pressure, tingling, itching, burning, abnormal local temperature sensation, or numbness at the bite site. In addition, percussive muscle edema (shrugging of the muscles at the site of percussion) may be present during the prodromal phase and throughout the course of the disease. This may be followed by progression to two major types of disease: encephalitic (manic) rabies and paralytic (mute) rabies. 1. Typical manifestations of encephalitis-type rabies include fever, fear of water, pharyngeal muscle spasms, and hyperactivity, which progresses to paralysis, coma, and death 2. Paralytic rabies: After the above precursor symptoms, the patient develops flaccid paralysis. The paralysis is usually most pronounced in the bitten limb and then spreads symmetrically or asymmetrically. Physical examination reveals muscle fasciculations; deep tendon and metatarsal reflexes are absent. Patients may complain of headache and pain in the affected muscles with mild sensory disturbances. Cervical ankylosis and cerebral nerve palsy are sometimes seen, while hydrophobia is uncommon. As the paralysis progresses, the patient develops severe paraplegia, loss of sphincter tone, followed by paralysis of the swallowing and respiratory muscles, and death.