There are many creams for treating acne. According to the different mechanisms of action, there are mainly retinoids, benzoyl peroxide gel and topical antibiotics. 1. Vitamin A acid: It can effectively treat acne by regulating follicle keratinization and inhibiting acne formation. Common drugs such as retinoic acid ointment, adapalene gel and so on. Initial use may cause local irritation, such as erythema, flaking, burning sensation, and should be used in low concentration or in a small area away from light. 2. Benzoyl peroxide gel: at the same time, it has the effect of oxidizing and sterilizing and dissolving acne, the side effects include itching, dryness, flaking, etc. It is forbidden for pregnant women, lactating women, and those with acute inflammation of the skin. 3. Topical antibiotics: mainly fusidic acid cream, erythromycin ointment, lincomycin and clindamycin, etc., which can effectively kill Propionibacterium acnes, and is prohibited for those with drug allergies. It is recommended to go to the dermatologist, under the guidance of the doctor for treatment, the specific use of drugs need to follow the doctor’s instructions.