Penile astringency, itching and tingling may be caused by glans, urethral stones, urethritis or cystitis, etc., and should be treated promptly under the guidance of a doctor to clarify the cause of the disease. 1. Glans: Glans is an inflammation of the mucous membrane of the glans, which can be caused by a variety of different reasons such as infection and local irritation. Glans inflammation may be manifested as symptoms of penile astringency, itching and tingling. 2. Urethral calculi: Urethral calculi belong to the lower urinary tract stones, most of them come from the stones formed in the kidneys and bladder, which are discharged into the urethra and stay in the bulbous part of the urethra or the navicular fossa and other places. Urethral calculi may be manifested as symptoms of penile astringency, itching and tingling. 3. Urethritis: Urethritis mainly refers to urethral infection caused by various pathogens. Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma, Trichomonas, herpes simplex virus, hepatitis virus and so on can cause this disease. Urethritis may be manifested as symptoms of penile astringency, itching and tingling. 4. Cystitis: Cystitis is an infection of the bladder mucosa, often accompanied by urethritis, collectively known as lower urinary tract infections. Cystitis may manifest itself in the form of painful itching and tingling in the penis. If you feel unwell, you should go to the hospital in time, so as not to delay the condition or cause adverse reactions.