Ibuprofen is not recommended for unexplained abdominal pain because its pharmacological action is a non-selective cyclooxygenase inhibitor, mainly anti-inflammatory, antipyretic and analgesic. It is mainly used in clinical practice for the treatment of rheumatoid arthritis, osteoarthritis, ankylosing arthritis, acute tendonitis, etc. Dysmenorrhea can also be used. In case of abdominal pain there are several mechanisms as follows: first, abdominal pain of visceral nature, such as lesions arising from the intestinal canal as well as the organs of the abdominal cavity, appendix, etc. causing nociceptive signals, which are usually not vaguely and precisely localized and have very serious concomitant symptoms, the misuse of ibuprofen cannot play a great role in relieving the pain and can mask part of the pain, leading to the local development of the lesion to form more serious complications. Secondly, somatic pain, whose localization is clear is usually caused by abdominal wall or abdominal muscle lesions, like localized abdominal muscle ankylosis, this situation can take ibuprofen. Third, abdominal pain is caused by involvement pain, that is, pain in the abdomen, but the lesion is not necessarily in the abdomen, the pain is severe, such as patients with heart attack manifested as pain in the upper abdomen, taking ibuprofen not only can not relieve, but also delay the treatment. Therefore, it is not advisable to take various analgesics for unexplained abdominal pain.