Drool rash in babies can be treated by promptly cleaning up the drool and applying moisturizing creams or hormonal ointments to the affected skin. When your baby has drool rash, the first thing to do is to take good localized care of the affected skin. When your baby drools, wipe the drool away to prevent it from eroding the affected skin. After wiping the drool off your baby, you can put moisturizing cream on the affected skin to keep it moist and speed up the recovery of drool rash. If your baby’s drool rash is more serious, such as localized breakouts and severe itching, you can use medications such as hydrocortisone butyrate cream to help your baby recover as soon as possible. All of the above medications should be used under medical supervision.