Sleeping up pain in the middle of the chest may be angina pectoris, pleurisy, heart attack, traumatic factors and other diseases. 1. angina: coronary artery stenosis and other factors can lead to vascular lumen occlusion, the imbalance between myocardial oxygen demand and supply of oxygen, which leads to myocardial ischemia and hypoxia, triggering angina pectoris, which will feel the pain in the middle of the chest. 2. pleurisy: pathogen infection, injury, malignant tumors and other reasons lead to pleurisy, the capillaries in the tissue will exude proteins, the formation of fibrous adhesions between the two layers of pleura, friction increases, which leads to chest pain and other related symptoms, mainly in the middle of the chest. 3. Cardiac infarction: it is high blood pressure and other reasons lead to atherosclerotic lesions in coronary artery vessels, causing narrowing or obstruction of the vascular lumen, resulting in myocardial ischemia, hypoxia, or necrosis leading to cardiac infarction, the most typical manifestation is chest pain. 4. Traumatic factors: if the patient in the sleep due to improper posture led to the chest area there is compression or other injuries caused by chest muscle strain, will also lead to the patient sleep up chest pain in the middle. Sleeping up chest pain in the middle of the cause more, if the symptoms of sleeping up chest pain in the middle of the chest, persistent unrelieved, need to timely medical treatment.