There is no such thing as the fastest and best way to treat periapical infection. Usually need to take drug treatment, surgical treatment. 1. Drug treatment: for patients with persistent inflammation and obvious symptoms of interstitial infection, it is necessary to use antibiotics such as metronidazole, ceftriaxone and cefuroxime, as well as non-steroidal anti-inflammatory painkillers such as ibuprofen and acetaminophen under the guidance of a doctor. 2. Surgical treatment: After the acute stage is relieved, the patient needs to actively cooperate with the doctor to carry out surgical treatment, and the commonly used surgical methods in the clinic include endodontic treatment, endodontic hemotransfer reconstruction, microscopic apical surgery, and tooth extraction. In general, most patients with periapical periodontitis have a good prognosis and can keep their teeth if they are treated in a timely and standardized manner. However, if the condition worsens due to untimely treatment, the prognosis is poorer due to complications such as cellulitis and osteomyelitis of the jaw. In conclusion, patients with apical periodontitis need to go to the hospital in a timely manner, cooperate with the doctor for active treatment, and strengthen oral care.