Children with abnormalities in non-invasive chromosome 22 may suffer from miscarriage, fetal congenital developmental abnormalities, pediatric Down syndrome, and tumors. When a pregnant woman has an abnormality of chromosome 22 during pregnancy, she may experience a miscarriage due to abnormal chromosome development, which may make it difficult for the embryo to become viable. If there is an abnormality of chromosome 22, it may also lead to abnormalities in the embryonic structure during the development of the fetus, and the fetus may have defects in the heart, kidneys, and other organs of the body, so it is recommended that pregnant women test themselves at any time during pregnancy, and also go to the hospital for a follow-up examination on time. If the fetus does not have any abnormalities of miscarriage during pregnancy, the fetus with chromosome 22 abnormality may be born with pediatric Down syndrome, and the child will have symptoms of backwardness of intelligence, special facial features, deformities, etc., and the child may have tumors in certain parts of the body or organs. Pregnant women with chromosome 22 abnormality should undergo further examination and seek medical review on time.