Perimembranous ventricular septal defect is a common type of ventricular septal defect, usually caused by genetics, viral infections, etc. Very small ventricular septal defects usually do not need to be treated, pay attention to daily to prevent infection endocarditis and follow the doctor’s instructions at any time to review can be, the condition of the more serious patients can be directly for surgical treatment, such as interventional therapy, intracardiac direct vision surgery. 1. Interventional therapy: Interventional therapy generally refers to ventricular septal defect occlusion, which is less traumatic and quicker recovery. It is generally applicable to simple ventricular septal defects at the age of ≥3 years with hemodynamic abnormality, and is susceptible to complications such as thrombus, residual shunt, arrhythmia, and migration of the blocker after surgery. 2. Intracardiac direct vision surgery: Intracardiac direct vision surgery refers to ventricular septal defect repair, after which patients may have complications such as cardiac conduction disorders, residual ventricular septal defects, and some of them may die. Specific treatments need to go to the hospital to confirm the diagnosis, under the guidance of the doctor to choose, the patient should go to the hospital regularly for review, the doctor can adjust the treatment program according to the review.