Clinically, enlarged lymph nodes are not necessarily due to AIDS, but may also be due to diseases such as lymphadenitis or lymph node tuberculosis. Therefore, in clinical practice, the patient’s clinical symptoms and medical history should be carefully questioned, the patient should be examined in detail, and then relevant auxiliary examinations should be combined to draw the correct conclusion. Generally speaking, lymph node enlargement caused by AIDS is accompanied by emaciation, fatigue, fever, and even pneumonia and tumor in some patients. Therefore, lymph node enlargement caused by AIDS is only one aspect, and patients will certainly be accompanied by systemic and systemic diseases. AIDS is a systemic immune disease and does not simply cause lymph node enlargement. In addition, if the patient has lymphadenitis, the patient will also have fever, usually after anti-inflammatory treatment, the patient’s lymph node swelling will gradually ease, or even disappear. In addition, if the patient is lymph node tuberculosis, the patient will have low-grade fever, night sweats and other discomforts, which must be carefully differentiated. Generally speaking, after anti-tuberculosis treatment for lymph node tuberculosis, the swelling of lymph nodes will be relieved.