Patients with chronic cholecystitis who do not have contraindications to levofloxacin hydrochloride can be treated with this medication. It should be noted that levofloxacin is not used to treat chronic cholecystitis in most cases, but can be used to treat the disease in combination with other bacterial infections. Levofloxacin is a fluoroquinolone antibacterial drug, which can be used for the treatment of hospital-acquired pneumonia, community-acquired pneumonia, acute exacerbation of chronic bronchitis, acute pyelonephritis caused by sensitive bacteria in adults; it is not suitable for people who are allergic to quinolones, pregnant or breastfeeding women, and people younger than 18 years old to be treated with this drug. Therefore, patients with chronic cholecystitis who do not have contraindications to levofloxacin hydrochloride can take this drug for treatment. Adverse reactions such as nausea, vomiting, headache, dizziness, tendonitis, worsening of myasthenia gravis may occur after taking the drug. It should also be noted that chronic cholecystitis without coexisting bacterial infection generally do not need to use antibiotic treatment, for chronic cholecystitis acute attack can be considered to use piperacillin, cefoperazone and other drugs, and levofloxacin is not as the first choice of drugs. Patients with chronic cholecystitis who need to be treated with levofloxacin are advised to use the drug under the guidance of a doctor.