Large B-cell lymphoma is the most common type of non-Hodgkin’s lymphoma, accounting for about 30% of non-Hodgkin’s lymphomas. It is a highly malignant lymphoma, and the first symptoms of patients are often painless lymph node enlargement, which can appear in the neck, armpit, groin, and supraclavicular area. In addition, in addition to swollen lymph nodes, large B-cell lymphoma is often associated with systemic symptoms, which may include fever, lethargy, and night sweats. In addition, if large B-cell lymphoma invades a local organ, it may also cause symptoms of local organ compression. If it invades the central nervous system, patients may exhibit a series of symptoms such as headache, nausea and diplopia. If it invades the urinary system, the patient may have back pain and urine loss. If it invades the stomach, the patient will also show symptoms such as abdominal pain, nausea, poor nausea and wasting.