Generalized itching in the elderly may be caused by simple pruritus, or it may be caused by endocrine metabolic system diseases, renal diseases and other secondary factors. 1. Simple pruritus: it is one of the most common causes of generalized itching in the elderly, mainly due to the physiological reduction of sebaceous membrane, interstitial lipids between keratinocytes and natural moisturizing factors caused by ageing, coupled with the dry air in winter, resulting in skin dryness, the skin’s barrier function is lowered, and the response to external stimuli is easy to occur. 2. Endocrine metabolic system diseases: mainly including diabetes mellitus, hyperthyroidism, hypothyroidism, gout and other endocrine metabolic system diseases may cause generalized itching of the skin in the elderly, such as diabetes mellitus due to the increase in blood glucose, susceptible to bacterial and fungal infections, coupled with diabetic neuropathy, can also lead to generalized itching of the skin. 3. Kidney disease: such as renal insufficiency of the population, there will be itchy skin, mainly in the elderly renal failure, when renal insufficiency, the body’s toxic metabolism is not out of the skin from thus stimulating the skin leading to itchy skin. In addition, allergies, chronic hepatitis and other liver and gallbladder diseases, anemia and other blood diseases, malignant tumors and other diseases can also lead to the symptoms of itchy skin in the elderly. When the elderly appear generalized skin itching, should be timely to the regular hospital, clear cause, and follow the doctor’s instructions for treatment.