Amenorrhea without endometrial growth may be a physiological phenomenon and does not require special treatment. If it is caused by uterine cavity adhesion, early onset ovarian insufficiency and other diseases, medication and surgical treatment should be taken according to the cause of the disease. 1. Physiological phenomenon: For 45-55-year-old women who have entered menopause, the endometrium does not grow and amenorrhea is a normal physiological phenomenon, indicating that with age, the ovaries naturally decline. 2. Uterine adhesion: common symptoms include amenorrhea and abdominal pain. Patients need to follow the doctor’s instructions to apply estrogen drugs, such as estradiol valerate tablets, estriol, etc., as well as a small dose of aspirin, which is conducive to the restoration of menstruation. For patients with severe disease, surgical treatment, such as hysteroscopic hysterosalpingectomy, should be considered. 3. Early-onset ovarian insufficiency: the main symptoms include amenorrhea, hot flashes and night sweats. Patients should follow the doctor’s instructions to apply estrogen drugs such as nilestrol and 17β-estradiol, and progesterone drugs such as micronized progesterone pills and progesterone capsules, or compound preparations such as estradiol dextroprogesterone and estradiol cyproterone. In summary, the endothelium does not grow amenorrhea if excluded is a physiological phenomenon, you need to go to the hospital in time to consult with the doctor and cooperate with the doctor active treatment.