The harmful effects of long-term use of Nitrendipine on the body include causing headache, dizziness, digestive irritation symptoms, transient hypotension, liver and kidney function impairment. Nitrendipine belongs to dihydropyridine calcium channel blockers, which can be clinically used in the treatment of coronary heart disease and hypertension. The drug can inhibit the transmembrane Ca2+ inward flow of vascular smooth muscle and dilate coronary arteries and renal arterioles to produce antihypertensive effects. The possible hazards of long-term use of the drug are as follows. 1. Headache and dizziness, which may be related to cerebral vasodilatation and can be tolerated by most patients. 2. Nausea, loss of appetite and other symptoms of digestive tract irritation, and the drug is considered to be related to the stimulation of the gastric mucosa, the use of gastric mucosal protective agents, if necessary, and the use of medication after meals can reduce the harm in this regard. 3. Transient hypotension, mostly seen in combination with other antihypertensive drugs, such as beta-blockers. At the initial stage of using the drug, some patients may also experience hypotension during the adjustment of the dosage, which can be tolerated. 4. Liver and kidney function damage, long-term use of the drug may be due to liver damage or kidney damage. Regular review of liver and kidney function is required. Use the drug with caution when abnormal liver or kidney function is found. It is contraindicated for those who are allergic to dihydropyridines and patients with severe aortic stenosis, and is contraindicated for women during pregnancy and lactation. It is recommended to use the drug under the guidance of a doctor in a scientific and standardized manner, and not to change the dosage of the drug without authorization.