Amoxicillin and neomycin can be combined.
1. Amoxicillin belongs to the β-lactam antibiotics, the mechanism of action of the drug is to inhibit the transpeptidase enzyme, preventing cross-linking between the peptide chain, leading to the bacterial cell wall mucopeptide synthesis is impeded, the water seeps into the bacterial body, the bacterium swells and dies, belongs to the reproduction phase bactericidal drugs. Amoxicillin has bactericidal effect on both gram-negative and gram-positive bacteria.
2. Neomycin belongs to aminoglycoside antibiotics, the mechanism of action of the drug is to inhibit the synthesis of bacterial proteins and destroy the integrity of the bacterial cell membrane, the role of the 30S subunit of the ribosome, belongs to the quiescent period of bactericidal drugs. Neomycin has a strong antibacterial effect on aerobic gram-negative bacilli.
Because the mechanism of action, period of action and antibacterial spectrum of amoxicillin and neomycin are different, so the two together can play a synergistic effect.
It should be noted that neomycin has nephrotoxicity and ototoxicity, patients suffering from kidney disease and hearing impairment should not use neomycin, amoxicillin may cause allergic reactions, amoxicillin is prohibited for patients allergic to penicillin.
It is recommended to use these two drugs reasonably under the guidance of a doctor, not unauthorized combination of drugs.