The most common cause of vaginal fissures is the irritation of the vulvar skin due to discharge caused by pathogenic bacterial infections, which leads to inflammation of the vulvar skin, resulting in breakage. The most common pathogenic infection is anaerobic bacterial infection, such as bacterial vaginosis caused by Gardnerella infection, which stimulates a local inflammatory reaction at the vaginal opening when the discharge flows to it. It is better to wash the vulva with 30% of cleanser and then insert the compound metronidazole suppository in the vagina for treatment and it is recommended to apply Bactrim to the vaginal opening for treatment. Do not have sexual intercourse during the treatment period and do not drink alcohol or eat spicy, acidic or stimulating food.