Eye pain after waking up may be caused by glaucoma, ocular inflammation, orbital space-occupying lesions, bright light stimulation in the morning, eye fatigue and other reasons. 1. Glaucoma: After glaucoma patients go to sleep at night, because of the change of body position, it can lead to the increase of intraocular pressure level of the patients, which can appear in the morning when they get up with sore eyes, and can also be accompanied by photophobia, fear of the wind, easy to flow tears, eye swelling feeling. In addition, glaucoma acute attack of intraocular pressure rises rapidly, and in severe cases, headache, vomiting and other discomforts will occur. 2. Ocular inflammation: patients with ocular inflammation such as conjunctivitis, keratitis, etc., under the stimulation of inflammation, patients may experience discomfort such as conjunctival congestion, photophobia, tearing, etc., and patients may also experience symptoms such as eye pain. 3. Orbital space-occupying lesions: tumor, inflammatory pseudotumor, hemangioma and other orbital space-occupying lesions, because the lesion volume increases and pushes the eyeball, patients may have eye pain and other discomforts. 4. Others: if the patient sleeps in a dark environment at night, and if the eye suddenly receives strong light stimulation when getting up in the morning, the patient may also have eye pain and other discomforts. If you stay up late the night before or use your eyes too much, your eyes can be dry, foreign body sensation and other discomforts, and patients can also experience eye pain. It is recommended that patients who wake up with significant eye pain should consult a doctor promptly to assess their condition and follow the doctor’s instructions for treatment.