A high total red blood cell count indicates that the volume of red blood cells in the peripheral blood is higher than the normal range, that is, the number of red blood cells contained in each milliliter of blood is higher than the normal range. Whether or not a high total red blood cell count is important depends on the cause of the high total red blood cell count and the specific degree of red blood cell increase. Chronic hypoxic diseases can cause a high total red blood cell count, such as chronic obstructive pulmonary disease, congenital cyanotic heart disease, etc. These chronic hypoxic diseases can cause a high total red blood cell count due to chronic hypoxia, resulting in an increased concentration of erythropoietin in the body. The severity of this condition often depends on the primary disease, such as chronic obstructive pulmonary disease, which often has an impact on the body’s cardiopulmonary function, and congenital cyanotic heart disease, which can also have serious consequences and requires active management. Common myeloproliferative disorders can also have high total erythrocyte count, such as true erythrocytosis, which can also have serious effects on the body, sometimes even causing acute leukemia, and require prompt treatment. So a high total red blood cell count often has serious consequences and the cause needs to be promptly identified and then treated accordingly.