Pregnant women with persistent vomiting and ketosis who suffer from hyperemesis gravidarum need to be hospitalized, including intravenous rehydration, multivitamin supplementation, correction of dehydration and electrolyte disorders, rational use of antiemetic medications, and prevention and treatment of complications. 1. General treatment and psychological support therapy: Avoid contact with odors, foods or additives that may induce vomiting. Avoid fasting in the morning, encourage small and frequent meals, drink water between meals, and eat light, dry and high-protein food. Medical staff and family members should give psychological guidance to the patients and inform them that after 2-3 days of active treatment, the condition will improve rapidly, and only a few pregnant women will have recurrence of symptoms after discharge and need to be re-admitted to the hospital. 2. Correct dehydration and electrolyte disorders. 3.Antiemetic treatment: Safety of antiemetic drugs: Since severe emetic occurs in early pregnancy, which is the most teratogenic and sensitive period for the fetus, the safety of antiemetic drugs is of great concern. (1) Vitamin B6 or vitamin B6-doxylamine combination: studies have confirmed that it is safe and effective for the application of early pregnancy hyperemesis, and it was approved by the U.S. Food and Drug Administration (FDA) in 2013 and recommended as a first-line drug [7], but doxylamine is not yet available in China. (2) Metoclopramide: Studies have shown that the application of metoclopramide during early pregnancy does not increase the risk of fetal malformation and spontaneous abortion. (3) Ondansetron: The American College of Obstetricians and Gynecologists (ACOG) recently concluded that although there is insufficient evidence to confirm the safety of ondansetron for the fetus, the absolute risk is low and should be used on a balance of benefits and disadvantages. (4) Promethazine: It has also been reported in the literature that although the use of promethazine in early pregnancy did not increase the incidence of birth defects, its continued use in late pregnancy may cause withdrawal effects and extrapyramidal reactions in the newborn. (5) Glucocorticoids: should be avoided as first-line agents before 10 weeks of gestation and used only as a last-resort antiemetic regimen for patients with intractable hyperemesis gravidarum.