The sudden onset of stomach pain at 2-3 a.m. may be considered to be due to duodenal ulcer. It may be due to acute gastritis or acute gastroenteritis due to a cold in the abdomen during the night while sleeping. For the inflammation of the stimulation is will cause pain, ulcer stimulation will also appear painful symptoms. Patients are advised to drink moderate amounts of warm water first, and if necessary, they can prepare their own acid-suppressing drugs for treatment, such as omeprazole or lansoprazole, ranitidine, etc. If the stomach pain is very severe, accompanied by chest tightness and chest pressure, be highly alert to the possibility of heart disease. It is recommended that patients need to go to the hospital promptly if necessary and cooperate with the doctor to give examination for detailed and clear diagnosis and treatment.