Mechanical friction, chickenpox or herpes zoster, herpetic dermatosis and so on may cause blisters to occur, which can be eliminated by local care and medication. 1. Mechanical friction: the palms of the hands, soles of the feet, toes and other parts of the body are often subject to mechanical friction, may make the local skin blisters, keratinous thickening and other manifestations, patients can use physiological saline or water for local cleaning, and then use a sterilized needle to pick the blisters, extraction of the blisters of the liquid, the operation of the local mupirocin ointment, clindamycin ointment ointment and other ointment, in order to avoid the occurrence of infection. 2. Chickenpox or herpes zoster: when the patient is infected by varicella-herpes zoster virus, it may cause chickenpox, herpes zoster occurs, so as to appear diffuse all over the body or along the nerve zones distribution of blisters, such patients can be applied locally to glycerine lotion, acyclovir cream, penciclovir cream and other creams for antiviral treatment, the symptoms of severe need to be taken orally at the same time aciclovir, vasiclovir, and other medications. 3. Herpetic dermatosis: pemphigus, herpetic pemphigoid and other herpetic dermatosis will also appear diffuse distribution of blisters, blisters and other symptoms, such patients can take glucocorticosteroid drugs (such as methylprednisolone tablets, trazodone tablets), immunosuppressants (such as azathioprine, moratorium on mescaline ester) to help the treatment, and at the same time pay attention to enhance the cleanliness and care of blister areas. It should be noted that the above treatments should be carried out under the guidance of a physician to avoid the occurrence of adverse reactions.