OA refers to a joint disease caused by a variety of factors that lead to fibrosis, cracking, ulceration, and loss of articular cartilage. The etiology is not clear, and its occurrence is related to age, obesity, inflammation, trauma, and genetic factors. Its pathology is characterized by degenerative destruction of articular cartilage, subchondral bone sclerosis or cystic changes, osteophytes at the joint edges, synovial hyperplasia, joint capsule contracture, ligament relaxation or curvature, and muscle atrophy and weakness. The prevalence of OA is more common in middle-aged and elderly patients, with more women than men. 50% of people over the age of 6O and 80% of people over the age of 75 have the disease. OA is more likely to occur in joints with high load, more activities, such as the knee, spine (cervical and lumbar spine), hip, ankle, hand and other joints. Clinical manifestations 1, joint pain and pressure pain: initially mild or moderate intermittent hidden pain, better at rest, increased after activity, pain is often related to weather changes. In the late stage, there may be persistent pain or nocturnal pain. There is localized pressure pain in the joints, which is especially obvious when accompanied by joint swelling. 2. Joint stiffness: stiffness and tightness of the joints when waking up in the morning, also known as morning stiffness, can be relieved after activity. Joint stiffness is aggravated when the air pressure decreases or the air humidity increases, and the duration is usually short, often a few minutes to ten minutes, rarely more than 30 minutes. 3. Joint enlargement: Enlargement and deformation of the hand joints are obvious, and Heberden’s nodes and Bouchard’s nodes may appear. Some of the knee joints may also be enlarged due to the formation of bone redundancy or joint effusion. 4. Bone rubbing sound (sensation): Due to the destruction of articular cartilage and uneven joint surface, bone rubbing sound (sensation) appears when the joint moves, mostly in the knee joint. 5, joint weakness, activity disorders: joint pain, decreased mobility, muscle atrophy, soft tissue contracture can cause joint weakness, walking leg weakness or joint locking, can not be completely straightened or activity disorders. Laboratory tests: routine blood, protein electrophoresis, immune complexes and serum complement are generally within the normal range. Patients with synovitis may have mildly elevated C-reactive protein (CRP) and hematocrit (ESR). Patients with secondary OA may present with abnormal laboratory tests of the primary disease. X-ray: asymmetric joint space narrowing, subchondral osteosclerosis and/or cystic changes, joint edge hyperplasia and osteophyte formation or with varying degrees of joint effusion, some intra-articular free bodies or joint deformation.