Taking tenofovir alanine aminotransferase from 30U/L to 86U/L is the manifestation of elevation, the main reasons include physiological factors, improper care, exacerbation of hepatitis B, etc. At present, we need to stay away from the causative factors as soon as possible, and timely and good day-to-day care, and need to take joint medication if necessary. 1. Physiological factors: at the beginning of taking tenofovir, it may lead to high ghrelin, which is a normal manifestation, and it can be restored to normal in three months or so without special treatment, but the dosage should be adjusted appropriately according to the progress of the disease. 2. Improper care: If you take tenofovir for a long time to treat hepatitis B, but don’t pay attention to reasonable diet, sleep and so on, it may lead to high ghrelin. At present, we should improve the bad living habits and dietary habits in time, and ensure enough sleep and less late night; for those who drink alcohol, they need to quit drinking in time. 3. Exacerbation of hepatitis B: some patients with hepatitis B have serious condition, even if they are taking tenofovir, the alanine aminotransferase may continue to increase. In this case, it is necessary to adjust the treatment program appropriately or combine with other antiviral drugs, such as entecavir; if the effect is not good, interferon injection can be considered. When taking tenofovir, you should know that if you are allergic to the ingredients of the drug, it should be prohibited during breastfeeding, and should be used with caution by women during pregnancy. Prolonged use of Tenofovir may cause dizziness, fever, abdominal pain and other symptoms, but can be relieved after stopping the drug in time, without special treatment. If you need to take Tenofovir, you should be under the guidance of a professional physician, and remember not to use the drug without authorization to avoid adverse reactions.