Ear cholesteatoma excision three months and then have granulation, should be further examination to determine whether the infection, or cholesteatoma recurrence, targeted treatment. 1. Infection: otitis externa or otitis media, inflammatory stimulation, may also cause localized inflammatory granulomatous hyperplasia, can be used externally ofloxacin ear drops, budesonide suspension; oral cephalosporin, amoxicillin, ofloxacin and other antibiotics anti-infection treatment. 2. Cholesteatoma recurrence: cholesteatoma may recur after surgery, which may also lead to the ear cholesteatoma excision months after the granulation, generally still need to be treated by surgical excision of cholesteatoma. Three months after the removal of cholesteatoma, there may be other reasons, you need to go to the hospital for examination, to clarify the cause of the disease and follow the doctor’s instructions for treatment.