Small holes on the soles of the feet are considered to be primarily related to fossa keratolysis. Fossa keratolytica may be a skin condition in which the metatarsal cuticle is exfoliated as a result of infection with Corynebacterium spp. The disease is usually characterized by scattered, superficial, soybean-sized rounded corneal erosions, which may appear as crater-like changes, and neighboring lesions may merge with each other to form irregular shapes, and the skin may be of normal color, brown, or black. Small holes in the soles of the feet may also be other diseases, such as warts or tinea pedis, when small holes in the soles of the feet appear, it is recommended to pay attention to foot hygiene, keep feet dry, try to choose breathable shoes, so as not to aggravate the symptoms. If the symptoms are serious, it is recommended to go to the hospital, clear the cause of the disease, under the guidance of the doctor for medication.