A negative test for antibodies specific for the syphilis spirochete suggests that there is no infection with the spirochete, that is, no syphilis. Syphilis is a contagious disease, which is mainly transmitted through sexual contact, and can invade our organs, causing damage to multiple organs. At present, clinical syphilis is mainly categorized into Stage I syphilis, Stage II syphilis and Stage III syphilis, and the most common is Stage I syphilis. The treatment for syphilis is mainly expulsion therapy, and the most common method is to use long-acting penicillin. The course of treatment is 2-3 weeks, and most patients’ clinical symptoms will improve after treatment. There is also a part of hidden syphilis patients, is the detection of syphilis diagnostic test is positive, but there is no clinical symptoms, such patients also need to carry on the expulsion of syphilis treatment.