There is no absolute fastest drug for the treatment of esophagitis. Depending on the typology, proton pump inhibitors, glucocorticosteroids, antifungal drugs, etc. are given. 1. Reflux esophagitis: it can be treated with proton pump inhibitors (omeprazole, lansoprazole), gastrointestinal stimulants (domperidone, mosapride) and other drugs. 2. Radiation esophagitis: patients with a history of radiation therapy can be treated with mucosal protective agents (aluminum thioglycollate), dexamethasone, lidocaine and other drugs. 3. Eosinophilic esophagitis: glucocorticoids (dexamethasone), leukotriene receptor antagonists (montelukast) and other drugs can be used for treatment. 4. Fungal esophagitis: Ketoconazole can be used for antifungal treatment. The above drugs are recommended to be used under medical supervision. When esophagitis occurs, it is recommended to go to the hospital and choose the appropriate drugs for treatment under the guidance of a doctor.