The treatment of chronic granulocytic leukemia to acute leukemia mainly includes clinical trials, supportive therapy, chemotherapy and hematopoietic stem cell transplantation. 1. Since the prognosis of chronic granulomonocytic leukemia is extremely poor once it turns into acute leukemia and the remission rate of ordinary chemotherapy is low, it is recommended to actively participate in any suitable clinical trials. 2. Supportive therapy is mainly based on the patient’s physical condition and abnormal examination indicators for anti-infection (such as cefepime, vancomycin, etc.), transfusion of blood products, nutritional supportive therapy. 3. Chemotherapy mainly includes demethylating drugs (5-azacytidine, etc.), pre-excitation chemotherapy or anthracycline drugs (e.g. Zoerythromycin) combined with cytarabine. After the disease is relieved by chemotherapy, allogeneic hematopoietic stem cell transplantation can be chosen according to age and physical condition. In conclusion, the treatment of patients with chronic granulomonocytic leukemia to acute leukemia is more complicated, and it is recommended to visit a hematology specialist to receive standardized treatment. The above medications should be used under the guidance of a specialist.