For those who are not satisfied with hyaluronic acid filler and want to have autologous fat filler, we often encounter it in the clinic. Some candidates think that hyaluronic acid is a synthetic product and have a certain rejection mentality towards it. There are also candidates who think that hyaluronic acid is not viable and it is very troublesome to come back again in half a year to a year. Some candidates think that the cross-linking agent of hyaluronic acid is harmful to human body, so they decide to inject hyaluronic acid dissolving enzyme and replace the filler from hyaluronic acid to fat. In fact, it varies from person to person as to when they can fill in fat after hyaluronic acid dissolution. Some candidates come all the way from out of town and just take a few days off. Then her need must be to have the procedure as soon as possible after the boat trip. In this case, the fat filler procedure can be performed a few hours after the hyaluronic acid lysozyme injection. From the practical point of view, a few hours after the injection of hyaluronic acid lysis enzyme, generally the dissolution has been completed in the location where it should be dissolved, but of course there are some tissue gaps that have not healed well and there are potential risks for fat filling. However, from the point of view of the surgical protocol and the actual clinical situation, it is also possible to do it. If there is no scheduling problem, fat filler can usually be done one week after the lysozyme injection. Usually one week after hyaluronic acid dissolution, the tissues start to flow with each other and the gap starts to heal gradually. At this time, it is relatively safe to carry out fat filling again. However, if there is really no time, filling fat the next day after lysozyme injection will not be a big problem, and there is room for flexible operation.