Sacubitril valsartan sodium tablets do not have the best time to take a say, the time of taking can choose to include the time of eating, or fasting two, pay attention to the contraindications of the drug and adverse reactions. Sacubitril valsartan sodium tablets are a combination of the enkephalinase inhibitor sacubitril and the angiotensin receptor antagonist valsartan, and are indicated for use in adult patients with chronic heart failure with a reduced ejection fraction NYHA classification of II to IV and a left ventricular ejection fraction of ≤40%, which may provide a modest reduction in the risk of cardiovascular death and hospitalization for heart failure. The drug is generally recommended to be taken with food or on an empty stomach, so these two options are the best timing choices for administration. Adverse reactions to the drug include angioedema, hypotension, renal impairment, and hyperkalemia. Contraindications to the drug include hypersensitivity to the product, patients with hereditary or idiopathic angioedema, presence of a previous history of angioedema associated with angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor antagonist therapy, severe hepatic impairment, biliary cirrhosis and cholestasis, and mid- to late-stage pregnancies, as well as prohibition of combining the drug with ACEI. In addition, the drug is prohibited in combination with Aliskiren in patients with type 2 diabetes. Specific use of the drug should be under the guidance of a specialist, and should not be used without authorization.